Chromothripsis in acute myeloid leukemia: biological features and impact on survival
Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one
or few chromosomes in multiple fragments and consequent random rejoining and repair.
This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid
leukemia (AML) patients from three institutions, its impact on survival and its genomic
background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples.
We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring …
or few chromosomes in multiple fragments and consequent random rejoining and repair.
This study defines incidence of chromothripsis in 395 newly diagnosed adult acute myeloid
leukemia (AML) patients from three institutions, its impact on survival and its genomic
background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples.
We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring …
[HTML][HTML] Chromothripsis in acute myeloid leukemia: biological features and impact on survival
Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one
or few chromosomes in multiple fragments and consequent random rejoining and repair.
This study define incidence of chromothripsis in 395 newly-diagnosed adult acute myeloid
leukemia (AML) patients from three institutions, its impact on survival and its genomic
background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples.
We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring …
or few chromosomes in multiple fragments and consequent random rejoining and repair.
This study define incidence of chromothripsis in 395 newly-diagnosed adult acute myeloid
leukemia (AML) patients from three institutions, its impact on survival and its genomic
background. SNP 6.0 or CytoscanHD Array (Affymetrix®) were performed on all samples.
We detected chromothripsis with a custom algorithm in 26/395 patients. Patients harboring …
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