Introduction People with hazardous alcohol use are more susceptible to viral, bacterial, and
fungal infections due to the effect of alcohol on immune system cell function. Metabolized
ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to
investigate whether alcohol is metabolized by bone marrow cells and if it impacts the
metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and
quantitative alteration of key metabolites which may be related to the immune response …

Methods We addressed this aim by using C57BL/6 mice under chronic ethanol
administration and evaluating the metabolomic profile of bone marrow total cells by gas
chromatography–coupled mass spectrometry (GC–MS). Results We identified 19
metabolites. Our data demonstrated that chronic ethanol administration alters the
metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of
five metabolites in ethanol-treated animals: uracil, succinate, proline, nicotinamide, and …