Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy
BACKGROUND: Psychologic stress modifies immune function and cytokine production.
OBJECTIVE: We examined relationships between caregiver stress on the following markers
of early childhood immune response:(1) IgE expression (n= 215);(2) mitogen-induced and
allergen-specific (Dermatophagoides farinae [Der f 1] and cockroach [Bla g 2]) proliferative
response (n= 114); and (3) subsequent cytokine expression (INF-γ, TNF-α, IL-10, and IL-13)
in a prospective birth cohort predisposed to atopy. METHODS: Caregiver stress was …
OBJECTIVE: We examined relationships between caregiver stress on the following markers
of early childhood immune response:(1) IgE expression (n= 215);(2) mitogen-induced and
allergen-specific (Dermatophagoides farinae [Der f 1] and cockroach [Bla g 2]) proliferative
response (n= 114); and (3) subsequent cytokine expression (INF-γ, TNF-α, IL-10, and IL-13)
in a prospective birth cohort predisposed to atopy. METHODS: Caregiver stress was …
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