Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis
via convergent signaling pathways that are impacted by diabetes. Here we asked how
glucose metabolism and important facets of insulin signaling are affected in the forebrain of
cannabinoid CB 1 receptor knockout mice (CB 1 R-KO) and their wild-type (WT) littermates,
seven weeks after the induction of insulinopenia/hyperglycemia (diabetes) with
intraperitoneal streptozotocin injection. Sham-injected animals served as control. Diabetes …
via convergent signaling pathways that are impacted by diabetes. Here we asked how
glucose metabolism and important facets of insulin signaling are affected in the forebrain of
cannabinoid CB 1 receptor knockout mice (CB 1 R-KO) and their wild-type (WT) littermates,
seven weeks after the induction of insulinopenia/hyperglycemia (diabetes) with
intraperitoneal streptozotocin injection. Sham-injected animals served as control. Diabetes …
以上显示的是最相近的搜索结果。 查看全部搜索结果