Chrysin prevents lipopolysaccharide-induced acute lung injury in mice by suppressing the IRE1α/TXNIP/NLRP3 pathway
M Chen, J Li, X Liu, Z Song, S Han, R Shi… - Pulmonary Pharmacology …, 2021 - Elsevier
Acute lung injury (ALI) remains a serious challenge in the intensive care unit. Inflammation
plays a key role in the progression of ALI. Chrysin (CHR) is a natural flavonoid with anti-
inflammatory functions. We investigated the anti-inflammatory effects in a mouse model of
ALI induced by lipopolysaccharide (LPS), and identified the underlying mechanisms of its
action. Following CHR administration, mice were challenged with LPS intratracheally for 6 h
to induce ALI. Compared to mice challenged with LPS alone, the presence of CHR showed …
plays a key role in the progression of ALI. Chrysin (CHR) is a natural flavonoid with anti-
inflammatory functions. We investigated the anti-inflammatory effects in a mouse model of
ALI induced by lipopolysaccharide (LPS), and identified the underlying mechanisms of its
action. Following CHR administration, mice were challenged with LPS intratracheally for 6 h
to induce ALI. Compared to mice challenged with LPS alone, the presence of CHR showed …
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