Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer

J Tie, JD Cohen, K Lahouel, SN Lo… - … England Journal of …, 2022 - Mass Medical Soc
… of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence
of circulating tumor DNA (ctDNA) … The benefit of adjuvant chemotherapy for ctDNA-positive …

Circulating tumor DNA in stage III colorectal cancer, beyond minimal residual disease detection, toward assessment of adjuvant therapy efficacy and clinical behavior …

TV Henriksen, N Tarazona, A Frydendahl… - Clinical Cancer …, 2022 - AACR
… detection and growth rate assessment provides unique opportunities for guidingctDNA
measurements have previously been reported in the context of stage II–III colorectal cancer (9). …

[HTML][HTML] Circulating tumor DNA analysis: potential to revise adjuvant therapy for stage II colorectal cancer

N Zhu, H Hu, Y Yuan - Signal Transduction and Targeted Therapy, 2022 - nature.com
… How long before the ctDNA-guided adjuvant chemotherapy of stage II CRC can reach …
Two ctDNA tests save nearly half of patients from adjuvant chemotherapy, which is highly …

[HTML][HTML] ctDNA to guide adjuvant therapy in localized colorectal cancer (CRC)

L Masfarré, J Vidal, C Fernández-Rodríguez… - Cancers, 2021 - mdpi.com
… as the detection of circulating tumor DNA (ctDNA) carrying tumor-… the most from a systemic
adjuvant treatment. Based on that … -operative ctDNA detection in stage II colon cancer patients. …

[HTML][HTML] ctDNA and adjuvant therapy for colorectal cancer: time to re-invent our treatment paradigm

M Naidoo, P Gibbs, J Tie - Cancers, 2021 - mdpi.com
… Recent technological advances in circulating tumour DNA (ctDNA… with stage II colon cancer
requiring adjuvant chemotherapy … and help guide adjuvant chemotherapy decision in stage II

Use of Circulating Tumor DNA to Guide Decision-making in Adjuvant Colon Cancer

Z Gottschalk, SA Cohen - Current Oncology Reports, 2024 - Springer
… of adjuvant chemotherapy in patients with colorectal cancer. Nat … of ctDNA-guided
management of stage II colon cancer as … ctDNA assays following surgery received less adjuvant

[HTML][HTML] Circulating Tumour DNA Guided Adjuvant Chemotherapy Decision Making in Stage II Colon Cancer—A Clinical Vignette Study

YH To, P Gibbs, J Tie, J Loree, T Glyn, K Degeling - Cancers, 2023 - mdpi.com
ctDNA testing to guide adjuvant chemotherapy decision making for patients with stage II colon
cancer. … ctDNA results would influence treatment recommendations in most patients, with …

[HTML][HTML] The promise of circulating tumor DNA (ctDNA) in the management of early-stage colon cancer: a critical review

S Chakrabarti, H Xie, R Urrutia, A Mahipal - Cancers, 2020 - mdpi.com
… implementation of ctDNA-based testing in guiding adjuvant therapy decisions and … stage
II colon cancer), randomization between standard therapy and ctDNA-guided adjuvant therapy

Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: Overall survival and updated 5-year results from the randomized DYNAMIC trial.

J Tie, Y Wang, SN Lo, K Lahouel, JD Cohen, R Wong… - 2024 - ascopubs.org
… a ctDNA-guided approach versus standard management in stage II colon cancer (CC) reduced
adjuvant chemotherapy (… MMR status defines two distinct subsets of stage II CC. Here, we …

Circulating tumour DNA as a potential cost-effective biomarker to reduce adjuvant chemotherapy overtreatment in stage II colorectal cancer

YH To, K Degeling, S Kosmider, R Wong, M Lee… - …, 2021 - Springer
… of care, using circulating tumour DNA to guide adjuvant chemotherapy reduced adjuvant
chemotherapyCirculating tumour DNA was found to be a potentially cost-effective biomarker in …