Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive
G Oberhofer, T Ivy, BA Hay - Proceedings of the National …, 2019 - National Acad Sciences
There is great interest in being able to spread beneficial traits throughout wild populations in
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element,
CleaveR [Cleave and Rescue (ClvR)], able to achieve this goal. ClvR comprises two linked
chromosomal components. One, germline-expressed Cas9 and guide RNAs (gRNAs)—the
Cleaver—cleaves and thereby disrupts endogenous copies of a gene whose product is
essential. The other, a recoded version of the essential gene resistant to cleavage and gene …
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element,
CleaveR [Cleave and Rescue (ClvR)], able to achieve this goal. ClvR comprises two linked
chromosomal components. One, germline-expressed Cas9 and guide RNAs (gRNAs)—the
Cleaver—cleaves and thereby disrupts endogenous copies of a gene whose product is
essential. The other, a recoded version of the essential gene resistant to cleavage and gene …
[引用][C] Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive
O Georg, I Tobin - 2019
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