Click reaction driven, highly fluorescent dinuclear organogold (I) complex exhibits a dual role: A rare Au··· H interaction and an antiproliferative agent
The metal–hydrogen (M··· H) bonds in transition elements are well documented. However,
the attractive AuI··· H bond interaction is rare and significant experimental evidence for it still
remains a challenge. Herein, we exhibit a rare example of a C–H··· Au interaction in both the
solid state and solution by employing a single-crystal X-ray diffraction study and NMR
spectroscopy for the novel dinuclear Au (I) complex 1, prepared by a click reaction between
organized and strained internal alkynes ((PPh3Au–C≡ C−) 2–C6H4) as reacting partners …
the attractive AuI··· H bond interaction is rare and significant experimental evidence for it still
remains a challenge. Herein, we exhibit a rare example of a C–H··· Au interaction in both the
solid state and solution by employing a single-crystal X-ray diffraction study and NMR
spectroscopy for the novel dinuclear Au (I) complex 1, prepared by a click reaction between
organized and strained internal alkynes ((PPh3Au–C≡ C−) 2–C6H4) as reacting partners …
The metal–hydrogen (M···H) bonds in transition elements are well documented. However, the attractive AuI···H bond interaction is rare and significant experimental evidence for it still remains a challenge. Herein, we exhibit a rare example of a C–H···Au interaction in both the solid state and solution by employing a single-crystal X-ray diffraction study and NMR spectroscopy for the novel dinuclear Au(I) complex 1, prepared by a click reaction between organized and strained internal alkynes ((PPh3Au–C≡C−)2–C6H4) as reacting partners. Furthermore, 1 was found to be highly fluorescent in nature and revealed remarkable antiproliferative properties against skin melanoma cell lines with IC50 values ranging from 3.12 to 8.5 μM.
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