Mechanisms underlying circadian clock function in Drosophila melanogaster have been
revealed by genetic and molecular approaches. Two interlocked transcriptional feedback loops …

… Biochemical studies indicate that the Drosophila timeless protein (Tim) is a stoichiometric …
the Drosophila circadian clock, and Tim degradation may be the initial response of the clock …

… Studies using the fruit fly Drosophila melanogaster have substantially enhanced our …
clock mechanisms. The genetic identification and isolation of the first clock gene in Drosophila, …

… The fact that all the parts of a clock mechanism are present does not ensure that the mechanism
necessarily produces a rhythm. Indeed, sustained oscillations of the limit cycle type only …

Circadian behavioral rhythms in Drosophila depend on the appropriate regulation of at least
two genes, period (per) and timeless (tim). Previous studies demonstrated that levels of …

… timing mechanisms that control the circadian clock, with a particular focus on Drosophila.
Analogous to transcriptional feedback regulation, circadian clock function in Drosophila …

… indicates that the two clock mechanisms include the rhythmic … is part of the intracellular
mechanism in both organisms (Hardin et al, … that have contributed to this Drosophila clock story. …

… signaling from clock neurons to the pars intercerebralis (PI), a clock output region regulating
… a link between Drosophila evening clock neurons and the PI, and find that the effect of clock …

… in the Drosophila model two different mechanisms by which the circadian repressor PERIOD
(PER) inhibits CLOCK/… They also suggest that these mechanisms occur upstream of post-…

… of several clock mutants. We also use the model to demonstrate how the Drosophila clock can
… of period or timeless, and propose a possible mechanism for oscillations in double-rescue …