… Here, we show the clonal evolution pattern in myelodysplastic syndrome (MDS) patients
receiving supportive care, with or without lenalidomide (follow-up 2.5–11 years). Whole-exome …

To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 patients, of …

… In each of the cases reported, clonal evolution occurred through the … that clonal evolution
could occur through either the linear evolution of subclones or branching evolution, with clonal …

… AML) progression in patients with myelodysplastic syndromes (MDS). However, to the authors'
knowledge, few data exist regarding the prognostic impact of cytogenetic clonal evolution …

… heterogeneous disorders driven by clonal … of clonal evolution in individual patients, we
differentiated isogenic MDS induced pluripotent stem cells harboring up to 4 successive clonal …

… of MDS predisposition syndromes. The effects of germline genetic context on the selective
pressures driving somatic clonal evolution are … Clonal evolution in myelodysplastic syndromes …

… disorders such as CMML and s-AML. Within our study we aimed to characterize clonal evolution
… clonal evolution focusing as well on distinct evolution patterns and the complexity of the …

… advantage of mutant cells over aging HSCs, and the risk to progression to myelodysplastic
syndrome (MDS) and transformation to acute myeloid leukemia (AML) is low. (b) In …

… To assess the acquisition of somatic mutations and clonal evolution during progression
from MDS to secondary AML, we evaluated paired bone marrow samples from 43 patients at …

… Early signs of clonal evolution may motivate treatment modification, such as switching from
… progression. The authors conclude that karyotyping is required to detect clonal evolution and …