Clonal Expansion of a Globally Disseminated Lineage of Mycobacterium tuberculosis with Low IS6110 Copy Numbers

RM Warren, TC Victor, EM Streicher… - Journal of clinical …, 2004 - Am Soc Microbiol
Knowledge of the clonal expansion of Mycobacterium tuberculosis and accurate
identification of predominant evolutionary lineages in this species remain limited, especially
with regard to low-IS 6110-copy-number strains. In this study, 170 M. tuberculosis isolates
with≤ 6 IS 6110 insertions identified in Cape Town, South Africa, were characterized by
principal genetic grouping, restriction fragment length polymorphism analysis, spoligotyping,
IS 6110 insertion site mapping, and variable-number tandem repeat (VNTR) typing. These …

[PDF][PDF] Clonal expansion of a globally disseminated lineage of Mycobacterium tuberculosis with low IS6110 copy numbers 5.

VN Chihota - … : Role in understanding disease dynamics in high …, 2011 - scholar.sun.ac.za
Abstract Knowledge of the clonal expansion of Mycobacterium tuberculosis and the accurate
identification of predominant evolutionary lineages remain limited in this species, especially
with regard to low-IS6110-copy-number strains. In this study, 170 M. tuberculosis isolates
with≤ 6 IS6110 insertions, identified in Cape Town, South Africa, were characterized by
principle genetic grouping, restriction fragment length polymorphism analysis, spoligotyping,
IS6110 insertion site mapping and variable number tandem repeat (VNTR) typing. This …
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