… the hypothesis that somatic mutations in hematopoietic cells contribute to the development
of human atherosclerosis. We propose that clonal hematopoiesis may be a modifiable risk …

Purpose of Review Clonal hematopoiesis (CH) is a prevalent condition that results from the
acquisition of somatic mutations in hematopoietic stem cells. When these mutations occur in “…

… the interplay between clonal hematopoiesis and atherosclerosis in a … clonal
hematopoiesis-related mutation confers an increased risk of developing de novo femoral …

… atherosclerosis patients is sufficient to produce a 3.5-fold increased risk of clonal hematopoiesis
… framework in mouse models of atherosclerosis and sleep fragmentation by showing that …

… increasing underlying atherosclerosis. We hypothesized that individuals with clonal
hematopoiesis also harbored a greater burden of subclinical coronary atherosclerosis before clinical …

… Clonal hematopoiesis has emerged as a major independent risk factor in atherosclerotic
cardiovascular … Studies in mouse models of clonal hematopoiesis have shown an increase in …

… In summary, our results support a causal link between exacerbated atherosclerosis and
clonal hematopoiesis induced by somatic mutations. Combined with the observations made in …

… of atherosclerosis. Recent experimental evidence suggests that clonal hematopoiesis (CH) …
contributes to the development of atherosclerosis and cardiac dysfunction and exacerbates …

… atherosclerotic diseases Next, we sought to understand whether the clonal hematopoiesis
putative driver gene differentially affected the risk of acquiring atherosclerosis. Previous work …

… clonal hematopoiesis of indeterminate potential (CHIP) display a puzzling propensity for
atherosclerosis, 1… We view atherosclerosis as an inflammatory disease that starts in the vascular …