Purpose Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition
characterized by somatic mutations in the blood of otherwise healthy adults. We
hypothesized that in patients undergoing autologous stem-cell transplantation (ASCT) for
lymphoma, CHIP at the time of ASCT would be associated with an increased risk of
myelodysplastic syndrome and acute myeloid leukemia, collectively termed therapy-related
myeloid neoplasm (TMN), and other adverse outcomes. Methods We performed whole …

Background Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related
phenomenon characterized by the presence of somatic mutations in peripheral blood
(PMIDs: 25426837, 25426838). Although CHIP was originally defined in healthy older adults
without cytopenias, it can be found in other contexts as well. For example, one recent report
described four patients with therapy-related myeloid neoplasm (TMN) arising after treatment
for other cancers, all of which were driven by TP53 mutations that could be found at very low …