Co-existence of BRAF V600E gene mutation in tumor and non-tumoral surrounding tissues in colorectal cancer
T Öztürk, B Toptaş-Hekimoğlu, AP Eronat, N Saygili… - in vivo, 2015 - iv.iiarjournals.org
Background/Aim: The murine sarcoma viral (V-Raf) oncogene homolog B (BRAF) V600E
mutation, which increases protein kinase activity in BRAF–mitogen-activated protein kinase
kinase (MEK)–extracellular signal-regulated kinases (ERK)(mitogen-activated protein
kinase (MAPK)) signaling, is found in 5-40% of all colorectal carcinoma cases. Proteins with
this mutation are reported to be 130-fold more active, which results in induced proliferation,
differentiation, cellular survival, and angiogenesis. The aim of the present study was to …
mutation, which increases protein kinase activity in BRAF–mitogen-activated protein kinase
kinase (MEK)–extracellular signal-regulated kinases (ERK)(mitogen-activated protein
kinase (MAPK)) signaling, is found in 5-40% of all colorectal carcinoma cases. Proteins with
this mutation are reported to be 130-fold more active, which results in induced proliferation,
differentiation, cellular survival, and angiogenesis. The aim of the present study was to …
Co-existence of BRAF V600E Gene Mutation in Tumor and Non-tumoral Surrounding Tissues in Colorectal Cancer
N Bassullu, HY Aydogan, S Goksel, AP Eronat… - 2015 - acikerisim.istanbul.edu.tr
Background/Aim: The murine sarcoma viral (V-Raf) oncogene homolog B (BRAF) V600E
mutation, which increases protein kinase activity in BRAF-mitogen-activated protein kinase
kinase (MEK)-extracellular signal-regulated kinases (ERK)(mitogen-activated protein kinase
(MAPK)) signaling, is found in 5-40% of all colorectal carcinoma cases. Proteins with this
mutation are reported to be 130-fold more active, which results in induced proliferation,
differentiation, cellular survival, and angiogenesis. The aim of the present study was to …
mutation, which increases protein kinase activity in BRAF-mitogen-activated protein kinase
kinase (MEK)-extracellular signal-regulated kinases (ERK)(mitogen-activated protein kinase
(MAPK)) signaling, is found in 5-40% of all colorectal carcinoma cases. Proteins with this
mutation are reported to be 130-fold more active, which results in induced proliferation,
differentiation, cellular survival, and angiogenesis. The aim of the present study was to …
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