[HTML][HTML] Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and …

ADAPT Research Group - Archives of neurology, 2008 - ncbi.nlm.nih.gov
ADAPT Research Group
Archives of neurology, 2008ncbi.nlm.nih.gov
… Whether better or poorer cognitive performance is caused by NSAID use is unknown,
and controlled clinical trials are required. We report the early results of such a primary
prevention trial. More than 2500 cognitively normal elderly participants in the … The
Alzheimer Disease Anti-inflammatory Prevention Trial is the first primary prevention trial to
test the association of NSAIDs with the incidence of AD and the change over time in
cognitive function in people without existing cognitive impairment. Other …
Abstract
Background
Observational studies have shown reduced risk of Alzheimer dementia in users of nonsteroidal anti-inflammatory drugs.
Objective
To evaluate the effects of naproxen sodium and celecoxib on cognitive function in older adults.
Design
ncbi.nlm.nih.gov
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