Colchicine for the treatment of patients with COVID-19: an updated systematic review and meta-analysis of randomised controlled trials
BMJ open, 2024•bmjopen.bmj.com
Objectives We conducted an updated systematic review and meta-analysis to investigate the
effect of colchicine treatment on clinical outcomes in patients with COVID-19. Design
Systematic review and meta-analysis. Data sources We searched PubMed, Embase, the
Cochrane Library, medRxiv and ClinicalTrials. gov from inception to January 2023. Eligibility
criteria All randomised controlled trials (RCTs) that investigated the efficacy of colchicine
treatment in patients with COVID-19 as compared with placebo or standard of care were …
effect of colchicine treatment on clinical outcomes in patients with COVID-19. Design
Systematic review and meta-analysis. Data sources We searched PubMed, Embase, the
Cochrane Library, medRxiv and ClinicalTrials. gov from inception to January 2023. Eligibility
criteria All randomised controlled trials (RCTs) that investigated the efficacy of colchicine
treatment in patients with COVID-19 as compared with placebo or standard of care were …
Objectives
We conducted an updated systematic review and meta-analysis to investigate the effect of colchicine treatment on clinical outcomes in patients with COVID-19.
Design
Systematic review and meta-analysis.
Data sources
We searched PubMed, Embase, the Cochrane Library, medRxiv and ClinicalTrials.gov from inception to January 2023.
Eligibility criteria
All randomised controlled trials (RCTs) that investigated the efficacy of colchicine treatment in patients with COVID-19 as compared with placebo or standard of care were included. There were no language restrictions. Studies that used colchicine prophylactically were excluded.
Data extraction and synthesis
We extracted all information relating to the study characteristics, such as author names, location, study population, details of intervention and comparator groups, and our outcomes of interest. We conducted our meta-analysis by using RevMan V.5.4 with risk ratio (RR) and mean difference as the effect measures.
Results
We included 23 RCTs (28 249 participants) in this systematic review. Colchicine did not decrease the risk of mortality (RR 0.99; 95% CI 0.93 to 1.05; I2=0%; 20 RCTs, 25 824 participants), with the results being consistent among both hospitalised and non-hospitalised patients. There were no significant differences between the colchicine and control groups in other relevant clinical outcomes, including the incidence of mechanical ventilation (RR 0.75; 95% CI 0.48 to 1.18; p=0.22; I2=40%; 8 RCTs, 13 262 participants), intensive care unit admission (RR 0.77; 95% CI 0.49 to 1.22; p=0.27; I2=0%; 6 RCTs, 961 participants) and hospital admission (RR 0.74; 95% CI 0.48 to 1.16; p=0.19; I2=70%; 3 RCTs, 8572 participants).
Conclusions
The results of this meta-analysis do not support the use of colchicine as a treatment for reducing the risk of mortality or improving other relevant clinical outcomes in patients with COVID-19. However, RCTs investigating early treatment with colchicine (within 5 days of symptom onset or in patients with early-stage disease) are needed to fully elucidate the potential benefits of colchicine in this patient population.
PROSPERO registration number
CRD42022369850.
bmjopen.bmj.com
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