Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome
EL Falcone, L Abusleme, M Swamydas, MS Lionakis… - Microbiome, 2016 - Springer
Background Chronic granulomatous disease (CGD) is caused by defects in nicotinamide
adenine dinucleotide phosphate oxidase 2 (NOX2) complex subunits (gp91 phox (aka
Nox2), p47 phox, p67 phox, p22 phox, p40 phox) leading to reduced phagocyte-derived
reactive oxygen species production. Almost half of patients with CGD develop inflammatory
bowel disease, and the involvement of the intestinal microbiome in relation to this
predisposing immunodeficiency has not been explored. Results Although CGD mice do not …
adenine dinucleotide phosphate oxidase 2 (NOX2) complex subunits (gp91 phox (aka
Nox2), p47 phox, p67 phox, p22 phox, p40 phox) leading to reduced phagocyte-derived
reactive oxygen species production. Almost half of patients with CGD develop inflammatory
bowel disease, and the involvement of the intestinal microbiome in relation to this
predisposing immunodeficiency has not been explored. Results Although CGD mice do not …
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