Collagen-induced arthritis in rats: antigen-specific suppression of arthritis and immunity by intravenously injected native type II collagen.
MA Cremer, AD Hernandez, AS Townes… - … (Baltimore, Md.: 1950 …, 1983 - journals.aai.org
Collagen-induced arthritis (CIA) developed in 70 to 90% of rats immunized with
heterologous type II collagen. CIA was reduced to 0 to 18% when rats were injected iv, ie,
pretreated, with 1 mg of soluble native type II collagen before immunization. Concomitant
with the suppression of CIA were significant suppression of IgM, IgG, and delayed-type
hypersensitivity (DTH) responses to type II collagen. Suppression of CIA and immunity to
collagen was antigen-specific, related to dose and route of administration, and occurred only …
heterologous type II collagen. CIA was reduced to 0 to 18% when rats were injected iv, ie,
pretreated, with 1 mg of soluble native type II collagen before immunization. Concomitant
with the suppression of CIA were significant suppression of IgM, IgG, and delayed-type
hypersensitivity (DTH) responses to type II collagen. Suppression of CIA and immunity to
collagen was antigen-specific, related to dose and route of administration, and occurred only …
[引用][C] Collagen-induced arthritis in rats: antigen-specific suppression of arthritis and immunity by intravenously injected native type II collagen
C MA - Journal of Immunology, 1983 - cir.nii.ac.jp
Collagen-induced arthritis in rats : antigen-specific suppression of arthritis and immunity by
intravenously injected native type II collagen | CiNii Research … Journal of Immunology
Journal of Immunology 131 2995-3000, 1983 …
intravenously injected native type II collagen | CiNii Research … Journal of Immunology
Journal of Immunology 131 2995-3000, 1983 …
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