Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model
BACKGROUND: Local delivery of temozolomide (TMZ) through polymers is superior to oral
administration in a rodent glioma model. OBJECTIVE: We hypothesized that the observed
clinical synergy of orally administered TMZ and carmustine (BCNU) wafers would translate
into even greater effectiveness with the local delivery of BCNU and TMZ and the addition of
radiotherapy in animal models of malignant glioma. METHODS: TMZ and BCNU were
incorporated into biodegradable polymers that were implanted in F344 rats bearing …
administration in a rodent glioma model. OBJECTIVE: We hypothesized that the observed
clinical synergy of orally administered TMZ and carmustine (BCNU) wafers would translate
into even greater effectiveness with the local delivery of BCNU and TMZ and the addition of
radiotherapy in animal models of malignant glioma. METHODS: TMZ and BCNU were
incorporated into biodegradable polymers that were implanted in F344 rats bearing …
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