Combinatorial rosamine library and application to in vivo glutathione probe
… Therefore, we envisioned that removal of the 2‘-carboxylic acid group from rhodamine (called
rosamine) will introduce flexibility onto the rhodamine scaffold and thus would generate a
possible sensor candidate whose fluorescence properties can be changed by an analyte
environment. Here we report the first combinatorial synthesis of a rosamine library and an in
vivo fluorescent probe for monitoring cellular glutathione (GSH) levels. … In summary, we have
developed the first rosamine library using solid-phase chemistry as a potential fluorescence …
rosamine) will introduce flexibility onto the rhodamine scaffold and thus would generate a
possible sensor candidate whose fluorescence properties can be changed by an analyte
environment. Here we report the first combinatorial synthesis of a rosamine library and an in
vivo fluorescent probe for monitoring cellular glutathione (GSH) levels. … In summary, we have
developed the first rosamine library using solid-phase chemistry as a potential fluorescence …
Combinatorial approach on fluorescent rosamine library was developed using solid-phase chemistry. A highly selective library member (H22) toward reduced glutathione (GSH) was discovered, demonstrating the capability of in vivo GSH level sensing in live cells.
ACS Publications以上显示的是最相近的搜索结果。 查看全部搜索结果