… somatic mutations in the replication repair machinery. All ultra-hypermutated cancers harbored
mutations … -hypermutated bMMRD cancers lacked mutations in polymerase genes (n = 17 …

… The rapid B cell proliferation that occurs during the response … Taken together, these results
show that neither the V region nor … levels of somatic mutation in unrearranged BCL-6 genes in …

… Our data pooled together with similar data obtained from … fusion would be advantageous for
the rapid and selective retrieval of … a mutation in a DNA replication factor resulting in reduced …

… cells of patients having a hereditary form of colon cancer. … 5) are rapidly emerging from
studies showing a connection … in eukaryotes) influence recombination processes between DNA …

… the wild-type allele owing to somatic mutation (60, 63) or loss … of the three genes function
together in mismatch correction. … occurs rapidly (halflife of 6-10 minutes), and that repair is …

… of HNPCC cases display abundant replication errors which are … described rapid damage
response pathway28 that results in … Indeed, combination of BRCA1 with BARD1, a potent …

… evolved as a rapid and efficient way to repair DSBs. Typically… based on a combination of
genetic and biophysical analyses … resolution of the blocked replication fork results in a half …

… Together, the variance of these component steps is … cells to replicate; (c) change nearby
DNA damage into mutations via … PGK1 showed strand specific rapid repair beginning 140 …

… genetic disorders that predispose to cancer through chromosome instability or the occurrence
of somatic mutations … to play a role in restarting DNA replication forks that are blocked at …

… of combined germ-line and somatic mosaicism is … rapid application of new technologies for
the study of DNA variation in disease. The results of these studies implicate somatic mutation …