Combining aldolases and transaminases for the synthesis of 2-amino-4-hydroxybutanoic acid
Amino acids are of paramount importance as chiral building blocks of life, for drug
development in modern medicinal chemistry, and for the manufacture of industrial products.
In this work, the stereoselective synthesis of (S)-and (R)-2-amino-4-hydroxybutanoic acid
was accomplished using a systems biocatalysis approach comprising a biocatalytic one-pot
cyclic cascade by coupling of an aldol reaction with an ensuing stereoselective
transamination. A class II pyruvate aldolase from E. coli, expressed as a soluble fusion …
development in modern medicinal chemistry, and for the manufacture of industrial products.
In this work, the stereoselective synthesis of (S)-and (R)-2-amino-4-hydroxybutanoic acid
was accomplished using a systems biocatalysis approach comprising a biocatalytic one-pot
cyclic cascade by coupling of an aldol reaction with an ensuing stereoselective
transamination. A class II pyruvate aldolase from E. coli, expressed as a soluble fusion …
Combining aldolases and transaminases for the synthesis of 2‑amino-4-hydroxybutanoic acid
K Hernández Sánchez, J Bujons, J Joglar Tamargo… - 2017 - digital.csic.es
Amino acids are of paramount importance as chiral building blocks of life, for drug
development in modern medicinal chemistry, and for the manufacture of industrial products.
In this work, the stereoselective synthesis of (S)-and (R)-2-amino-4-hydroxybutanoic acid
was accomplished using a systems biocatalysis approach comprising a biocatalytic one-pot
cyclic cascade by coupling of an aldol reaction with an ensuing stereoselective
transamination. A class II pyruvate aldolase from E. coli, expressed as a soluble fusion …
development in modern medicinal chemistry, and for the manufacture of industrial products.
In this work, the stereoselective synthesis of (S)-and (R)-2-amino-4-hydroxybutanoic acid
was accomplished using a systems biocatalysis approach comprising a biocatalytic one-pot
cyclic cascade by coupling of an aldol reaction with an ensuing stereoselective
transamination. A class II pyruvate aldolase from E. coli, expressed as a soluble fusion …
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