Comparative efficacy and safety of three current clinical treatments for girls with central precocious puberty: a network meta-analysis

Q Gu, Y Luo, J Ye, X Shen - Endocrine Practice, 2019 - Elsevier
Objective: The optimal treatment for girls with central precocious puberty (CPP) is unknown.
We conducted a network meta-analysis to evaluate the efficacy and safety of existing
treatments to provide credible clinical guidelines. Methods: We compared gonadotropin-
releasing hormone analogue (GnRHa) therapy, GnRHa plus growth hormone (GH)
combination therapy, and no-treatment therapy for girls with CPP by performing an
electronic search for studies in PubMed, Embase, Chinese National Knowledge …
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