Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice
Spectinamides are a novel series of spectinomycin analogs being developed for the
treatment of tuberculosis. Intrapulmonary aerosol (IPA) administration of lead spectinamide
1599 has previously been shown to be more efficacious than subcutaneous (SC)
administration at comparable doses. The objective of the current study was to characterize
the disposition of 1599 in plasma and lungs in mice in order to provide a potential rationale
for the observed efficacy differences. 200 mg/kg of 1599 was administered to healthy BALB/c …
treatment of tuberculosis. Intrapulmonary aerosol (IPA) administration of lead spectinamide
1599 has previously been shown to be more efficacious than subcutaneous (SC)
administration at comparable doses. The objective of the current study was to characterize
the disposition of 1599 in plasma and lungs in mice in order to provide a potential rationale
for the observed efficacy differences. 200 mg/kg of 1599 was administered to healthy BALB/c …
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