Comparison of normal saline and balanced crystalloid (plasmalyte) in patients undergoing elective craniotomy for supratentorial brain tumors: a randomized controlled …

A Dey, S Adinarayanan, PU Bidkar, RK Bangera… - Neurology …, 2018 - journals.lww.com
Background: The choice of fluid is important in neurosurgical patients, who may be
dehydrated due to the administration of diuretics in order to reduce cerebral edema. Normal
saline, the infused fluid routinely used in neurosurgical patients, can cause hyperchloremic
metabolic acidosis. A balanced crystalloid (BC) may help to maintain the metabolic status
more favorably in these patients, without adversely affecting brain relaxation. Methods: We
conducted a prospective, randomized controlled trial on patients undergoing elective …
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