Comparison of systemic mycophenolate mofetil with topical clobetasol in lichen planopilaris: a parallel-group, assessor-and analyst-blinded, randomized controlled …
American journal of clinical dermatology, 2015•Springer
Introduction Lichen planopilaris (LPP) is the most common cause of inflammatory immune-
mediated cicatricial alopecia. If not diagnosed and treated properly, it may lead to
irreversible hair loss with a devastating impact on quality of life. However, treatment can be a
challenge. In an area lacking these sorts of studies, we conducted a randomized controlled
trial (RCT) to study the tolerability and therapeutic effects of topical clobetasol versus
systemic mycophenolate mofetil (MMF). Methods A randomized, assessor-and analyst …
mediated cicatricial alopecia. If not diagnosed and treated properly, it may lead to
irreversible hair loss with a devastating impact on quality of life. However, treatment can be a
challenge. In an area lacking these sorts of studies, we conducted a randomized controlled
trial (RCT) to study the tolerability and therapeutic effects of topical clobetasol versus
systemic mycophenolate mofetil (MMF). Methods A randomized, assessor-and analyst …
Introduction
Lichen planopilaris (LPP) is the most common cause of inflammatory immune-mediated cicatricial alopecia. If not diagnosed and treated properly, it may lead to irreversible hair loss with a devastating impact on quality of life. However, treatment can be a challenge. In an area lacking these sorts of studies, we conducted a randomized controlled trial (RCT) to study the tolerability and therapeutic effects of topical clobetasol versus systemic mycophenolate mofetil (MMF).
Methods
A randomized, assessor- and analyst-blinded controlled trial was conducted in 60 patients with LPP in Razi Dermatology Hospital, Tehran, Iran, between February and December 2013. Patients were treated with clobetasol lotion 0.05 % applied at night or oral MMF 2 g/day and were followed for 6 months. The Lichen Planopilaris Activity Index (LPPAI) was the primary measure of response to treatment.
Results
Systemic MMF and topical clobetasol were equally effective in reducing the LPPAI over 6 months of treatment. Treatment tolerability was excellent in both groups and no serious irreversible adverse effects were detected. Satisfaction with treatment rose in the MMF group over time; however, it declined in the clobetasol group.
Conclusion
Given the similar efficacy profiles, topical clobetasol seems to be a more suitable and reasonable choice for treatment of LPP than MMF.
Springer
以上显示的是最相近的搜索结果。 查看全部搜索结果