Background: This study was aimed at comparing the efficacy of different routes of
misoprostol administration, including sublingual, oral, and vaginal, on the induction of
medical abortion in the first trimester of pregnancy. Materials and Methods: This open-label,
randomized clinical trial study was performed on 172 individuals in three parallel groups of
vaginal, sublingual, and oral administration of misoprostol. The participants were
randomized using permuted blocks of six. A dose of 600 μg of misoprostol every 6 h …