Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects
Background: Several studies of healthy volunteers have revealed that subjective mood may
vary with the duration of prior wakefulness and with the time of day. However, in these
studies, the effects of extended wakefulness and circadian phase remained confounded,
and the interaction of these 2 processes could not be assessed quantitatively. Methods: In
the present study, a total of 24 healthy young subjects (16 men, 8 women) lived on a 30-hour
sleep-wake schedule for 19 to 23 days or on a 28-hour sleep-wake schedule for 33 to 36 …
vary with the duration of prior wakefulness and with the time of day. However, in these
studies, the effects of extended wakefulness and circadian phase remained confounded,
and the interaction of these 2 processes could not be assessed quantitatively. Methods: In
the present study, a total of 24 healthy young subjects (16 men, 8 women) lived on a 30-hour
sleep-wake schedule for 19 to 23 days or on a 28-hour sleep-wake schedule for 33 to 36 …
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