Conjugate additions to alkynylalkoxycarbenemetal (Cr or W) complexes
The addition of different nucleophilic compounds (aliphatic and aromatic alcohols, thiols and
phosphines) to alkynylalkoxycarbene complexes has been studied. The reaction with
smaller nucleophiles proceeds readily and regioselectively at the β-carbene position. With
more substituted nucleophiles the reaction rate slowed down considerably. Addition of a
catalytic amount of DBU (1, 8-di-azabicyclo [5.4. 0] undec-7-ene]) speeded up the reaction
and improved the E/Z ratio.
phosphines) to alkynylalkoxycarbene complexes has been studied. The reaction with
smaller nucleophiles proceeds readily and regioselectively at the β-carbene position. With
more substituted nucleophiles the reaction rate slowed down considerably. Addition of a
catalytic amount of DBU (1, 8-di-azabicyclo [5.4. 0] undec-7-ene]) speeded up the reaction
and improved the E/Z ratio.
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