Conjugative plasmid protein TrwB, an integral membrane type IV secretion system coupling protein: detailed structural features and mapping of the active site cleft
Bacterial conjugation is an example of macromolecular trafficking between cells and
responsible for the spreading of antibiotic resistance among bacteria. It involves
translocation of single-stranded DNA across membranes through a type IV secretion system.
A coupling protein links the DNA-processing nucleoprotein complex, the relaxosome, with
the transport apparatus during cell mating. In Escherichia coli plasmid R388 such a protein
is TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein. TrwB is …
responsible for the spreading of antibiotic resistance among bacteria. It involves
translocation of single-stranded DNA across membranes through a type IV secretion system.
A coupling protein links the DNA-processing nucleoprotein complex, the relaxosome, with
the transport apparatus during cell mating. In Escherichia coli plasmid R388 such a protein
is TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein. TrwB is …
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