As rates of separation and divorce among African Americans increase exponentially, development of effective treatment approaches for this population is particularly essential. Cognitivebehavioral treatment approaches targeting African American couple relationships by necessity must consider several risk factors specific to these couples, including experiences of racism and economic stress, as well as incorporate cultural resources and supports that may render these couples resilient to these stressors. In an attempt to foster cultural competence in the application of cognitive-behavioral approaches in treating distressed African American couples, this article reviews current research on the impact of culture-specific stressors and resources on African American couple relationships; discusses strategies for addressing biases, power, and privilege issues among therapists and clients; and highlights newer integrative treatment approaches and strategies for their potential in addressing diversity.