[HTML][HTML] Convergence of reinforcing and anhedonic cocaine effects in the ventral pallidum
Neuron, 2016•cell.com
Addiction is a disorder of behavioral symptoms including enhanced incentive salience of
drug-associated cues, but also a negative affective state. Cocaine-evoked synaptic plasticity
in the reward system, particularly the nucleus accumbens (NAc), drives drug-adaptive
behavior. However, how information is integrated downstream of the NAc remains unclear.
Here, we identify the ventral pallidum (VP) as a site of convergence of medium spiny
neurons expressing dopamine (DA) receptor type 1 (D1-MSNs) and type 2 (D2-MSNs) of the …
drug-associated cues, but also a negative affective state. Cocaine-evoked synaptic plasticity
in the reward system, particularly the nucleus accumbens (NAc), drives drug-adaptive
behavior. However, how information is integrated downstream of the NAc remains unclear.
Here, we identify the ventral pallidum (VP) as a site of convergence of medium spiny
neurons expressing dopamine (DA) receptor type 1 (D1-MSNs) and type 2 (D2-MSNs) of the …
Summary
Addiction is a disorder of behavioral symptoms including enhanced incentive salience of drug-associated cues, but also a negative affective state. Cocaine-evoked synaptic plasticity in the reward system, particularly the nucleus accumbens (NAc), drives drug-adaptive behavior. However, how information is integrated downstream of the NAc remains unclear. Here, we identify the ventral pallidum (VP) as a site of convergence of medium spiny neurons expressing dopamine (DA) receptor type 1 (D1-MSNs) and type 2 (D2-MSNs) of the NAc. Repeated in vivo cocaine exposure potentiated output of D1-MSNs, but weakened output of D2-MSNs, occluding LTP and LTD at these synapses, respectively. Selectively restoring basal transmission at D1-MSN-to-VP synapses abolished locomotor sensitization, whereas restoring transmission at D2-MSN-to-VP synapses normalized motivational deficits. Our results support a model by which drug-evoked synaptic plasticity in the VP mediates opposing behavioral symptoms; targeting the VP may provide novel therapeutic strategies for addictive disorders.
cell.com
以上显示的是最相近的搜索结果。 查看全部搜索结果