The diffusion tensor image analysis along the perivascular space (DTI-ALPS) method was
proposed to evaluate glymphatic system (GS) function. However, few studies have validated
its reliability and reproducibility. Fifty participants DTI data from the MarkVCID consortium
were included in this study. Two pipelines by using DSI studio and FSL software were
developed for data processing and ALPS index calculation. The ALPS index was obtained
by the average of bilateral ALPS index and was used for testing the cross-vendor, inter-rater …

Background Glymphatic system (GS) is a recently discovered brain‐wide perivascular fluid
transport system in the cerebral nervous system (CNS)(Benveniste H et al., 2019) The
impairment of glymphatic transport has been demonstrated to be associated with several
neurological diseases, in particular the vascular cognitive impairment and dementia
(VCID)(Tang J et al., 2022). The diffusion tensor analysis along the perivascular space (DTI‐
ALPS) was proposed to non‐invasively evaluate the GS clearance dysfunction which has …