[PDF][PDF] Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
NE Bhola, JR Grandis - Front Biosci, 2008 - article.imrpress.com
NE Bhola, JR Grandis
Front Biosci, 2008•article.imrpress.com… Growth factor receptors that are implicated in cancer development and/or progression
include the epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGF-R),
fibroblast growth factor receptor (FGF-R) and plateletderived growth factor receptor (PDGFR). …
With respect to cancer, ADAM17 overexpression was observed and shown to mediate
GPCR-induced ligand-dependent activation of EGFR in colon cancer (33, 34). Along with
colon cancer, GPCR-EGFR crosstalk in non-small cell lung cancer, HNSCC and pancreatic …
include the epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGF-R),
fibroblast growth factor receptor (FGF-R) and plateletderived growth factor receptor (PDGFR). …
With respect to cancer, ADAM17 overexpression was observed and shown to mediate
GPCR-induced ligand-dependent activation of EGFR in colon cancer (33, 34). Along with
colon cancer, GPCR-EGFR crosstalk in non-small cell lung cancer, HNSCC and pancreatic …
Abstract
Introduction 3. Epidermal growth factor receptor 4. G-protein-coupled receptors 5. Transactivation of EGFR in cancer 5.1. Colon cancer
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