Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling
J Jia, L Zhu, X Yue, S Tang, S Jing, C Tan, Y Du… - Cell Communication and …, 2024 - Springer
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic
reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to
tumorigenic effects. However, the molecular mechanism underlying these effects is largely
unknown. In this study, we reveal that the last four residues of ER chaperones, which are
recognized by KDEL receptor (KDELR), is required for cell proliferation and migration
induced by secreted chaperones. By combining proximity-based mass spectrometry …
reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to
tumorigenic effects. However, the molecular mechanism underlying these effects is largely
unknown. In this study, we reveal that the last four residues of ER chaperones, which are
recognized by KDEL receptor (KDELR), is required for cell proliferation and migration
induced by secreted chaperones. By combining proximity-based mass spectrometry …
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling Short title: KDELR regulates EGFR-STAT3 …
J Jia, X Yue, S Tang, S Jing, L Zhu, C Tan, Y Du, J Gao… - 2023 - researchsquare.com
Hostile microenvironment of cancer cells provoke a stressful condition for endoplasmic
reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to
tumorigenic effects. However, the molecular mechanism underlying these effects is largely
unknown. In this study, we reveal that the last four residues of ER chaperones, which are
recognized by KDEL receptor (KDELR), is required for cell proliferation and migration
induced by secreted chaperones. By combining proximity-based mass spectrometry …
reticulum (ER) and stimulate the expression and secretion of ER chaperones, leading to
tumorigenic effects. However, the molecular mechanism underlying these effects is largely
unknown. In this study, we reveal that the last four residues of ER chaperones, which are
recognized by KDEL receptor (KDELR), is required for cell proliferation and migration
induced by secreted chaperones. By combining proximity-based mass spectrometry …
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