[HTML][HTML] Cu (II) benzoylpyridine thiosemicarbazone complexes: Inhibition of human topoisomerase IIα and activity against breast cancer cells
JD Conner, W Medawala, MT Stephens… - Open Journal of …, 2016 - scirp.org
The focus of this research is on the study of a series of copper (II) benzoylpyridine
thiosemicarbazone complexes. Of the six benzoylpyridine thiosemicarbazone ligands used
in this study, two are reported for the first time; 2-benzoylpyridine tert-butyl
thiosemicarbazone (BZP-tBTSC), and 2-benzoylpyridine benzyl thiosemicarbazone (BZP-
BzTSC). Once characterized by NMR, melting point, and MS, these mono-anionic tridentate
ligands were then reacted with Cu2+ to form the new square planar metal complexes [Cu …
thiosemicarbazone complexes. Of the six benzoylpyridine thiosemicarbazone ligands used
in this study, two are reported for the first time; 2-benzoylpyridine tert-butyl
thiosemicarbazone (BZP-tBTSC), and 2-benzoylpyridine benzyl thiosemicarbazone (BZP-
BzTSC). Once characterized by NMR, melting point, and MS, these mono-anionic tridentate
ligands were then reacted with Cu2+ to form the new square planar metal complexes [Cu …