Curcumin based pyrazole-thiazole hybrids as antiproliferative agents: Synthesis, pharmacokinetic, photophysical properties, and docking studies
A series of new curcumin pyrazole-thiazole hybrids (C 1-C 8) were synthesized and
characterized by fundamental spectral analysis. The synthesized compounds were tested for
antiproliferative activity against the colorectal cancer cell line (COLO-205), breast cancer cell
line (MCF-7), liver cancer cell line (HepG-2), lung cancer cell line (A549), and cervical
cancer cell line (HeLa) using cisplatin as a positive control. The compounds C 7 (IC 50
values of 8.57±1.09 µM for COLO-205, 9.22±0.73 µM for MCF-7, 16.95±1.16 µM for HepG-2 …
characterized by fundamental spectral analysis. The synthesized compounds were tested for
antiproliferative activity against the colorectal cancer cell line (COLO-205), breast cancer cell
line (MCF-7), liver cancer cell line (HepG-2), lung cancer cell line (A549), and cervical
cancer cell line (HeLa) using cisplatin as a positive control. The compounds C 7 (IC 50
values of 8.57±1.09 µM for COLO-205, 9.22±0.73 µM for MCF-7, 16.95±1.16 µM for HepG-2 …
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