It is well known that the presence of a blood–brain barrier (BBB) makes drug delivery to the
brain more challenging. There are various mechanistic routes through which therapeutic
molecules travel and deliver the drug across the BBB. Among all the routes, the transcellular
route is widely explored to deliver therapeutics. Advances in nanotechnology have
encouraged scientists to develop novel formulations for brain drug delivery. In this article, we
have broadly discussed the BBB as a limitation for brain drug delivery and ways to solve it …

It is well known that the presence of a blood–brain barrier (BBB) makes drug delivery to the
brain more challenging. There are various mechanistic routes through which therapeutic
molecules travel and deliver the drug across the BBB. Among all the routes, the transcellular
route is widely explored to deliver therapeutics. Advances in nanotechnology have
encouraged scientists to develop novel formulations for brain drug delivery. In this article, we
have broadly discussed the BBB as a limitation for brain drug delivery and ways to solve it …