The human homologue of Drosophila Toll (hToll), also called Toll-like receptor 4 (TLR4), is a
recently cloned receptor of the IL-1/Toll receptor family. Interestingly, the TLR4 gene has
been localized to the same region to which the Lps locus (endotoxin unresponsive gene
locus) is mapped. To examine the role of TLR4 in LPS responsiveness, we have generated
mice lacking TLR4. Macrophages and B cells from TLR4-deficient mice did not respond to
LPS. All these manifestations were quite similar to those of LPS-hyporesponsive C3H/HeJ …

Cutting Edge : Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to
lipopolysaccharide : evidence for TLR4 as the Lps hene product | CiNii Research … Cutting
Edge : Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide :
evidence for TLR4 as the Lps hene product …