Cyclin D1 Genetic Heterozygosity Regulates Colonic Epithelial Cell Differentiation and Tumor Number in ApcMin Mice
…, Z Li, C Albanese, M Rao, D Di Vizio… - … and cellular biology, 2004 - Taylor & Francis
… , of cyclin D1 conveys tumor resistance remains to be established. We investigated the role
of cyclin D1 in colonic epithelial cell differentiation, proliferation, and tumor formation induced …
of cyclin D1 in colonic epithelial cell differentiation, proliferation, and tumor formation induced …
[HTML][HTML] Differential regulation of cyclin D1 expression by protein kinase C α and ϵ signaling in intestinal epithelial cells
… PKCϵ also up-regulates cyclin D1 expression in colon cancer cells, through mechanisms that
… Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor …
… Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor …
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial …
T Zhang, LB Nanney, C Luongo, L Lamps, KJ Heppner… - Cancer research, 1997 - AACR
… Genetic linkage studies have shown that macti vation of the Apc gene … intestinal epithelium
cell line (IEC-6) that expresses abundant levels of Cdk4 were used as the positive controls for …
cell line (IEC-6) that expresses abundant levels of Cdk4 were used as the positive controls for …
Cyclin D2–cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss
AM Cole, K Myant, KR Reed, RA Ridgway, D Athineos… - Cancer research, 2010 - AACR
… Apc loss in the murine intestinal epithelium, and our data … of cyclin D1 heterozygosity in the
context of cyclin D2 genetic … roles that cyclins D1 and D2 play in intestinal tumorigenesis are …
context of cyclin D2 genetic … roles that cyclins D1 and D2 play in intestinal tumorigenesis are …
Cycling D1 negatively regulates the expression of differentiation genes in HT-29 M6 mucus-secreting colon cancer cells
C Mayo, X Mayol - Cancer letters, 2009 - Elsevier
… M6 colon cancer cells differentiate to a mucus-secreting phenotype in culture. We found that
the pattern of cyclin D1 expression in HT-29 M6 cells did not correlate with instances of cell …
the pattern of cyclin D1 expression in HT-29 M6 cells did not correlate with instances of cell …
Heterozygosity of p21WAF1/CIP1 Enhances Tumor Cell Proliferation and Cyclin D1-associated Kinase Activity in a Murine Mammary Cancer Model
JM Jones, XS Cui, D Medina, LA Donehower - 1999 - AACR
… duplication of the genetic complement of the cell and the segregation … regulated through a
series of cell cycle checkpoints that serve to regulate the progression from one stage of the cell …
series of cell cycle checkpoints that serve to regulate the progression from one stage of the cell …
Contribution of cyclin D1 (CCND1) and E-cadherin (CDH1) alterations to colorectal cancer susceptibility: a case–control study
… We conducted a genetic association study in South Indian population (cases, 103; controls,
… The homozygotes manifested as a single peak, whereas the heterozygotes as double peaks…
… The homozygotes manifested as a single peak, whereas the heterozygotes as double peaks…
PKCα tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1
MA Pysz, OV Leontieva, NW Bateman, JM Uronis… - Experimental cell …, 2009 - Elsevier
… as the intestinal epithelium is a key step in tumor development… a key role of this isozyme in
regulating intestinal self-renewal. … lost in intestinal tumors of diverse genetic backgrounds and …
regulating intestinal self-renewal. … lost in intestinal tumors of diverse genetic backgrounds and …
[HTML][HTML] Reelin protects from colon pathology by maintaining the intestinal barrier integrity and repressing tumorigenic genes
AE Carvajal, JM Serrano-Morales… - … et Biophysica Acta (BBA …, 2017 - Elsevier
… cells differentiate as they move up to the surface epithelium … − ) mice were obtained by
heterozygous crossings. The animals were … up-regulates Smad5 and Cyclin D1 in the reeler colon, …
heterozygous crossings. The animals were … up-regulates Smad5 and Cyclin D1 in the reeler colon, …
[HTML][HTML] New roles of cyclin D1
RG Pestell - The American journal of pathology, 2013 - Elsevier
… for p27 Kip1 binding in this stem cell differentiation function. … genes, was repressed in
expression and activity by cyclin D1, … regulated in cyclin D1–induced transgenic mammary tumors …
expression and activity by cyclin D1, … regulated in cyclin D1–induced transgenic mammary tumors …