… , of cyclin D1 conveys tumor resistance remains to be established. We investigated the role
of cyclin D1 in colonic epithelial cell differentiation, proliferation, and tumor formation induced …

… PKCϵ also up-regulates cyclin D1 expression in colon cancer cells, through mechanisms that
… Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor …

… Genetic linkage studies have shown that macti vation of the Apc gene … intestinal epithelium
cell line (IEC-6) that expresses abundant levels of Cdk4 were used as the positive controls for …

… Apc loss in the murine intestinal epithelium, and our data … of cyclin D1 heterozygosity in the
context of cyclin D2 genetic … roles that cyclins D1 and D2 play in intestinal tumorigenesis are …

… M6 colon cancer cells differentiate to a mucus-secreting phenotype in culture. We found that
the pattern of cyclin D1 expression in HT-29 M6 cells did not correlate with instances of cell …

… duplication of the genetic complement of the cell and the segregation … regulated through a
series of cell cycle checkpoints that serve to regulate the progression from one stage of the cell …

… We conducted a genetic association study in South Indian population (cases, 103; controls,
… The homozygotes manifested as a single peak, whereas the heterozygotes as double peaks…

… as the intestinal epithelium is a key step in tumor development… a key role of this isozyme in
regulating intestinal self-renewal. … lost in intestinal tumors of diverse genetic backgrounds and …

… cells differentiate as they move up to the surface epithelium … − ) mice were obtained by
heterozygous crossings. The animals were … up-regulates Smad5 and Cyclin D1 in the reeler colon, …

… for p27 Kip1 binding in this stem cell differentiation function. … genes, was repressed in
expression and activity by cyclin D1, … regulated in cyclin D1–induced transgenic mammary tumors …