P450s are known to be critical for the detoxification and/or activation of xenobiotics such as
drugs and pesticides and overexpression of P450 genes can significantly affect the
disposition of xenobiotics in the tissues of organisms, altering their pharmacological/
toxicological effects. In insects, P450s play an important role in detoxifying exogenous
compounds such as insecticides and plant toxins and their overexpression can result in
increased levels of P450 proteins and P450 activities. This has been associated with …