Cytochrome b 5 augments the 17, 20-lyase activity of human P450c17 without direct electron transfer
RJ Auchus, TC Lee, WL Miller - Journal of Biological Chemistry, 1998 - ASBMB
In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both
the 17α-hydroxylation of 21-carbon steroids and the 17, 20-lyase activity that cleaves the C
17-C 20 bond to produce C 19 sex steroids. Cytochrome b 5 augments the 17, 20-lyase
activity of cytochrome P450c17 in vitro, but this has not been demonstrated in membranes,
and the mechanism of this action is unknown. We expressed human P450c17, human P450-
oxidoreductase (OR), and/or human cytochromeb 5 in Saccharomyces cerevisiae and …
the 17α-hydroxylation of 21-carbon steroids and the 17, 20-lyase activity that cleaves the C
17-C 20 bond to produce C 19 sex steroids. Cytochrome b 5 augments the 17, 20-lyase
activity of cytochrome P450c17 in vitro, but this has not been demonstrated in membranes,
and the mechanism of this action is unknown. We expressed human P450c17, human P450-
oxidoreductase (OR), and/or human cytochromeb 5 in Saccharomyces cerevisiae and …
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