… response to clopidogrel appear to be at increased risk for cardiovascular events. Clopidogrel
is a prodrug that requires biotransformation to an active metabolite by cytochrome P-450 (…

… infarction (MI) treated with clopidogrel are unknown. … polymorphisms (SNPs) in selected
cytochrome P (CYP) genes with plasma concentrations of the active metabolite of clopidogrel …

… functional polymorphisms have been found in genes encoding cytochrome P-450 isoforms
involved in clopidogrel … response to clopidogrel has not been systematically investigated. …

… This polymorphism did not influence platelet aggregation profiles. No association was observed
between the other polymorphisms and clopidogrel responsiveness… clopidogrel response …

… Compared with CYP3A4, the effect of CYP3A5 polymorphism on clopidogrel response …
polymorphism played a minor role in causing inter-individual variability of clopidogrel response (…

… as well as the clinical response to clopidogrel, with genetic polymorphisms in CYP genes …
Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360:…

… we review the role of clopidogrel resistance focusing on … cytochrome P polymorphisms and
their role in clopidogrel efficacy and clinical utility. CYTOCHROME P450 AND CLOPIDOGREL…

… clopidogrel resistance and CYP2C19 polymorphism. We required that the patients be given
clopidogrel for at least six days before the clopidogrel … , CYP2C19 polymorphism testing was …

… in vivo validation in healthy volunteers identified polymorphisms in cytochrome P450 (CYP)
3A4 … with altered clopidogrel response, since generation of clopidogrel active metabolite is, …

… Aims: Clopidogrel is an antiplatelet drug primarily used to treat or prevent acute ischemic …
metabolite by cytochrome P450 (CYP) enzymes, and CYP single nucleotide polymorphisms (…