Regulation of PDGF and its receptors in fibrotic diseases

JC Bonner - Cytokine & growth factor reviews, 2004 - Elsevier
… as idiopathic pulmonary fibrosis (IPF) and a number of fibrotic … While IFN-γ mediates many
of its actions through the STAT-1 … extensive cross-talk that modulates signals in a positive or …

Arachidonic acid metabolites: potential mediators and therapeutic targets in fibrotic lung disease

M Peters-Golden - Idiopathic pulmonary fibrosis, 2003 - taylorfrancis.com
… increased amounts of the antifibrotic cytokines IFN-γ and IL-10. … mediators (eg, cytokines)
each modulate the production of … prednisolone, and cis-4hydroxyproline on pulmonary fibrosis

Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19

V Maldonado, MA Loza-Mejia, J Chavez-Alderete - Medical hypotheses, 2020 - Elsevier
… that immunosuppression with corticosteroids impairs the … production of the cytokines IL-1,
IL-6, IL-8, and IFN-γ. Along … Treg/Th17 balance by modulating Foxp3 and RORγt transcription …

[HTML][HTML] Plasticity towards rigidity: A macrophage conundrum in pulmonary fibrosis

E Sari, C He, C Margaroli - International journal of molecular sciences, 2022 - mdpi.com
steroids have been the cornerstone for maintenance therapy … process mediator TGF-β and
modulating cytokines … by increased release of IFN-γ, TNF-α, IL-12, IL-1β, IL-6, and IL-10 by …

Serum levels of galectin-3 in idiopathic inflammatory myopathies: a potential biomarker of disease activity

E Watanabe, K Kato, T Gono, E Chiba, C Terai… - …, 2021 - academic.oup.com
… administration of corticosteroids and/or other immunosuppressants. … by modulating the
production of various cytokines and … with serum proinflammatory cytokines IL-6, IL-8, IFN-γ, TNF-α, …

Platelet-Derived Growth Factor–Producing CD4+ Foxp3+ Regulatory T Lymphocytes Promote Lung Fibrosis

S Lo Re, M Lecocq, F Uwambayinema… - … and critical care …, 2011 - atsjournals.org
… investigated by exploring fibrotic responses of IFN-γ–, IL-4–, … with anti-CD4 antibody treatment
or steroids (dexamethasone) (22, 23… that the Th1 cytokine IFN-γ also possesses antifibrotic …

[HTML][HTML] Macrophage metabolic reprogramming during chronic lung disease

PP Ogger, AJ Byrne - Mucosal immunology, 2021 - Elsevier
… potential of corticosteroid prednisone, immunosuppressant … of pro-inflammatory cytokines,
modulating AM phenotype198, … HIF1α and interferon-gamma (IFN-γ). This metabolic shift and …

Pharmacological treatment of idiopathic pulmonary fibrosis: an update

P Spagnolo, AU Wells, HR Collard - Drug Discovery Today, 2015 - Elsevier
… to this paradigm and focused on modulation of wound-healing … -1b (IFN-γ-1b) is an
endogenously produced cytokine with … patients with IPF were randomly assigned to either …

[HTML][HTML] COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
… For example, treatment with corticosteroids has been found … IFN-γ protects type 1 pneumocytes
against SARS-Cov-1 infection … Glucocorticoids may also modulate inflammation-mediated …

Mechanisms of action and clinical application of macrolides as immunomodulatory medications

S Kanoh, BK Rubin - Clinical microbiology reviews, 2010 - Am Soc Microbiol
Modulation of this channel may be a promising treatment for … a shift from Th1 to Th2 cytokine
production after the use of … the expression of ICAM-1 on IFN-γ-treated epithelial cells (133). It …