… Administration of IFN-γ, an immunomodulatory cytokine, has … This trial enrolled 826 patients
with IPF to receive either IFN-γ … by modulating the expression of pro-fibrotic cytokines such as …

… We hypothesized that, IL-4 and IL-13 can directly modulate the behavior of lung fibroblasts.
… (DEX), a potent corticosteroid. As a Th1 type cytokine, IFN-γ counteracted the effect of IL4 …

… Initially, corticosteroids and immunosuppressants were used to treat IPF … treatment
guidelines for IPF strongly recommended against use of corticosteroids and immunosuppressants …

… of corticosteroids apply to … IFN-γ inhibits a fibrogenic growth factor produced by mast cells,
fibroblast growth factor-2 (FGF-2, basic FGF) (37), and a variety of neutrophil-derived cytokines …

… and antifibrotic cytokines in the lungs of patients with IPF led … of inhaled IFN-γ found that
patients in the treatment group … Connective tissue growth factor (CTGF) is known to modulate …

… target and modulate our immune system in patients with IPF. … pathogenesis, treatments that
modulate inflammation (eg steroids) … in pulmonary fibrosis needs further research, cytokines …

… agents and/or Th1 cytokines, in particular by IFN-γ, is mainly … with any anti-inflammatory or
immunosuppressive drug for at … anti-inflammatory cytokine IL-10 significantly modulates this IL…

… , including corticosteroids and immunosuppressive agents, have … Exogenous IFN-γ has
been shown to modulate macrophage and … of profibrotic cytokines. In view of these properties, …

… pulmonary fibrosis: Pro-Inflammatory cytokines are responsible for activation of alveolar
inflammatory pathways. IL-17AR operates IL-17A activating the prime modulator … -γ (IFN-γ) and IL…

… shown to be a modulator of cytokines and growth factors, … of IFN-γ, which is known to be an
anti-fibrotic cytokine through … -steroid agents for the treatment of IPF and identified IFN-γ-1b …