… for a cytokine used therapeutically to modulate the fibrotic … therapy for IPF that use steroids
and immunosuppressive agents… documented capacity to induce IFN-γ, we report here that IL…

… T-helper type 1/Th2 cytokine expression, with Th2 cytokines … In mice, daily treatment with
IFN-γ following bleomycin injury … 40 in IPF patients who had failed to respond to corticosteroids. …

… followed by analysis of the cytokines IFN-γ, IL-4, IL-6, IL-17A, IL-23… and its modulation by the
addition of immunosuppressive … with corticosteroids and tacrolimus supports our hypothesis …

… , including corticosteroids and immunosuppressive agents, have … Exogenous IFN-γ has
been shown to modulate macrophage and … of profibrotic cytokines. In view of these properties, …

… For example, TNF interacts with IL-1 or IFN-γ to … Treatment with corticosteroids decreases
the levels of TNF, IL… level and activity of that cytokine can be modified to modulate its effects on …

… Fibrocytes also secrete a variety of fibrogenic cytokines, growth factors, and other mediators
that modulate fibrosis. The major mediators that are expressed by fibrocytes and the …

… ‐2, IFN‐γ is the main effector cytokine of the so‐called type 1 … I and II expression, thus
modulating cytotoxic and helper T cell… (‘timing’ of cytokine polarization) or after …

… 1 (Th1) cytokines [interferon-γ (IFN-γ)], IL-2, or T helper 2 (Th2) … suggest that IFN-γ –induced
CXC chemokines modulate … corticosteroid or immunosuppressive treatment of fibrotic lung …

… to corticosteroids and other immunosuppressive drugs. This … assess their modulation with
immunosuppressive therapy in … of inflammatory cytokines IL-17A, IL-17F, IL-22, and IFN-γ, …

… that corticosteroid treatment … modulation of mRNAs for cytokines and chemokines which
have been implicated to play a role in the pulmonary fibrotic process (such as MCP-1, IL-6, IFN-γ…