[HTML][HTML] Cytokine profile in elderly patients with sepsis
Indian Journal of Critical Care Medicine: Peer-reviewed, Official …, 2009•ncbi.nlm.nih.gov
Objectives: Serial estimation of Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-
α) and their correlation with mortality in sepsis in elderly patients and to determine the
influence of gender on cytokine production and mortality in elderly patients with sepsis.
Settings and Design: The prospective study was conducted at our tertiary care center from
April 2007 to September 2008. Elderly Patients satisfying the Systemic Inflammatory
Response Syndrome (SIRS) criteria were included. Methods and Material: TNF-α and IL-6 …
α) and their correlation with mortality in sepsis in elderly patients and to determine the
influence of gender on cytokine production and mortality in elderly patients with sepsis.
Settings and Design: The prospective study was conducted at our tertiary care center from
April 2007 to September 2008. Elderly Patients satisfying the Systemic Inflammatory
Response Syndrome (SIRS) criteria were included. Methods and Material: TNF-α and IL-6 …
Objectives:
Serial estimation of Interleukin-6 (IL-6) and Tumor Necrosis Factor-Alpha (TNF-α) and their correlation with mortality in sepsis in elderly patients and to determine the influence of gender on cytokine production and mortality in elderly patients with sepsis.
Settings and Design:
The prospective study was conducted at our tertiary care center from April 2007 to September 2008. Elderly Patients satisfying the Systemic Inflammatory Response Syndrome (SIRS) criteria were included.
Methods and Material:
TNF-α and IL-6 were estimated in 30 elderly patients admitted to our intensive care unit with SIRS and sepsis. The estimations were done on day 1, 3 and 7 of admission.
Statistical Analysis Used:
Student and paired ‘t’tests, and ANOVA, which were further followed up by post-hoc ‘t’tests with Bonferroni correction using SPSS.
Results:
Reducing levels of IL-6 levels from day 1 to 7 was found in the survivor group. TNF-α level was significantly low on day 1 in the nonsurvivor female group.
Conclusions:
Serial estimation of cytokines in elderly patients with sepsis will help in prediction of mortality. Female gender was an independent predictor of increased morality in critically ill patients with sepsis.
ncbi.nlm.nih.gov
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