DD3PCA3-based molecular urine analysis for the diagnosis of prostate cancer
D Hessels, JMTK Gunnewiek, I van Oort… - European urology, 2003 - Elsevier
Background: DD3PCA3 is the most prostate cancer-specific gene described to date. To
assess the clinical utility of DD3PCA3 a time-resolved fluorescence-based, quantitative RT-
PCR analysis for DD3PCA3 was developed. Methods: The diagnostic potential of DD3PCA3
was determined by quantitative measurement of DD3PCA3 transcripts in non-malignant and
malignant prostate specimens. Moreover, DD3PCA3 transcripts were determined
quantitatively in urine sediments obtained after prostatic massage. A cohort of 108 men …
assess the clinical utility of DD3PCA3 a time-resolved fluorescence-based, quantitative RT-
PCR analysis for DD3PCA3 was developed. Methods: The diagnostic potential of DD3PCA3
was determined by quantitative measurement of DD3PCA3 transcripts in non-malignant and
malignant prostate specimens. Moreover, DD3PCA3 transcripts were determined
quantitatively in urine sediments obtained after prostatic massage. A cohort of 108 men …
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