DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn,
coordinates DNA damage checkpoint activation and promotes the removal of DNA lesions.
In recent years, several studies have shown how the DDR and the immune system are
tightly connected, revealing an important crosstalk between the two of them. This interesting
interplay has opened up new perspectives in clinical studies for immunological diseases as …

DNA damage plays a causal role in numerous human pathologies including cancer,
premature aging, and chronic inflammatory conditions. In response to genotoxic insults, the
DNA damage response (DDR) orchestrates DNA damage checkpoint activation and
facilitates the removal of DNA lesions. The DDR can also arouse the immune system by for
example inducing the expression of antimicrobial peptides as well as ligands for receptors
found on immune cells. The activation of immune signaling is triggered by different …