DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia
Introduction In looking for novel non-amyloid-based etiologies for Alzheimer's disease, we
explore the hypothesis that age-related myelin loss is an attractive explanation for age-
associated cognitive decline and dementia. Methods We performed a meta-analysis of data
in the National Alzheimer's Coordinating Center database accompanied by quantitative
histopathology of myelin and oligodendrocytes (OLs) in frontal cortices of 24 clinically
characterized individuals. Pathological findings were further validated in an Alzheimer's …
explore the hypothesis that age-related myelin loss is an attractive explanation for age-
associated cognitive decline and dementia. Methods We performed a meta-analysis of data
in the National Alzheimer's Coordinating Center database accompanied by quantitative
histopathology of myelin and oligodendrocytes (OLs) in frontal cortices of 24 clinically
characterized individuals. Pathological findings were further validated in an Alzheimer's …
[PDF][PDF] DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's and dementia
Introduction: In looking for novel non-amyloid-based etiologies for Alzheimer's disease, we
explore the hypothesis that age-related myelin loss is an attractive explanation for age-
associated cognitive decline and dementia. Methods: We performed a meta-analysis of data
in the National Alzheimer's Coordinating Center database accompanied by quantitative
histopathology of myelin and oligodendrocytes (OLs) in frontal cortices of 24 clinically
characterized individuals. Pathological findings were further validated in an Alzheimer's …
explore the hypothesis that age-related myelin loss is an attractive explanation for age-
associated cognitive decline and dementia. Methods: We performed a meta-analysis of data
in the National Alzheimer's Coordinating Center database accompanied by quantitative
histopathology of myelin and oligodendrocytes (OLs) in frontal cortices of 24 clinically
characterized individuals. Pathological findings were further validated in an Alzheimer's …
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